Histopathology of Brugia malayi -infected nude mice after immune-reconstitution
Identifieur interne : 00D778 ( Main/Exploration ); précédent : 00D777; suivant : 00D779Histopathology of Brugia malayi -infected nude mice after immune-reconstitution
Auteurs : A. C. Vickery [États-Unis] ; K. H. Albertine [États-Unis] ; J. K. Nayar [États-Unis] ; B. H. Kwa [États-Unis]Source :
- Acta Tropica [ 0001-706X ] ; 1991.
Descripteurs français
- KwdFr :
- Animaux, Brugia, Cellules géantes de Langhans (anatomopathologie), Fibrose, Filariose lymphatique (), Filariose lymphatique (anatomopathologie), Filariose lymphatique (immunologie), Granulome (anatomopathologie), Immunothérapie adoptive, Lymphocytes (anatomopathologie), Macrophages (anatomopathologie), Microscopie électronique, Modèles animaux de maladie humaine, Mâle, Souris, Souris nude, Système lymphatique (anatomopathologie), Système lymphatique (ultrastructure).
- MESH :
- anatomopathologie : Cellules géantes de Langhans, Filariose lymphatique, Granulome, Lymphocytes, Macrophages, Système lymphatique.
- immunologie : Filariose lymphatique.
- Animaux, Brugia, Fibrose, Filariose lymphatique, Immunothérapie adoptive, Microscopie électronique, Modèles animaux de maladie humaine, Mâle, Souris, Souris nude, Système lymphatique.
English descriptors
- KwdEn :
- Animals, Brugia, Brugia malayi, Disease Models, Animal, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (pathology), Elephantiasis, Filarial (therapy), Fibrosis, Filariasis, Giant Cells, Langhans (pathology), Granuloma (pathology), Immunotherapy, Adoptive, Lymphatic System (pathology), Lymphatic System (ultrastructure), Lymphatics, Lymphocytes (pathology), Macrophages (pathology), Male, Mice, Mice, Nude, Microscopy, Electron, Nude mice, Reconstitution.
- MESH :
- immunology : Elephantiasis, Filarial.
- pathology : Elephantiasis, Filarial, Giant Cells, Langhans, Granuloma, Lymphatic System, Lymphocytes, Macrophages.
- therapy : Elephantiasis, Filarial.
- ultrastructure : Lymphatic System.
- Animals, Brugia, Disease Models, Animal, Fibrosis, Immunotherapy, Adoptive, Male, Mice, Mice, Nude, Microscopy, Electron.
Abstract
Long term (>200 day) Brugia malayi-infected nude mice with grossly dilated lymphatics were reconstituted with 108 primed spleen cells from heterozygous donors. Histological and ultrastructural examination at 7, 14, 21 and 28 days post-reconstitution revealed progressive fibrosis, obliterative lymph thrombus formation, interstitial infiltrates and extensive perilymphangitis. Formation of lymph thrombi/granulomas was associated with killing of adult worms and microfilariae, and the predominant cell types involved were large granular macrophages, Langhan's giant cells and eosinophils. Thus, the ability to initiate the formation of obstructive lesions in the dilated lymphatics of chronically parasitized nude mice by immunological reconstitution, suggests that several complex mechanisms might operate in stages to cause filarial elephantiasis.
Url:
DOI: 10.1016/0001-706X(91)90029-J
Affiliations:
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Histological and ultrastructural examination at 7, 14, 21 and 28 days post-reconstitution revealed progressive fibrosis, obliterative lymph thrombus formation, interstitial infiltrates and extensive perilymphangitis. Formation of lymph thrombi/granulomas was associated with killing of adult worms and microfilariae, and the predominant cell types involved were large granular macrophages, Langhan's giant cells and eosinophils. Thus, the ability to initiate the formation of obstructive lesions in the dilated lymphatics of chronically parasitized nude mice by immunological reconstitution, suggests that several complex mechanisms might operate in stages to cause filarial elephantiasis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li><li>Pennsylvanie</li></region><settlement><li>Tampa</li></settlement><orgName><li>Université de Floride du Sud</li></orgName></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Vickery, A C" sort="Vickery, A C" uniqKey="Vickery A" first="A. C." last="Vickery">A. C. Vickery</name></region><name sortKey="Albertine, K H" sort="Albertine, K H" uniqKey="Albertine K" first="K. H." last="Albertine">K. H. Albertine</name><name sortKey="Kwa, B H" sort="Kwa, B H" uniqKey="Kwa B" first="B. H." last="Kwa">B. H. Kwa</name><name sortKey="Nayar, J K" sort="Nayar, J K" uniqKey="Nayar J" first="J. K." last="Nayar">J. K. 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